Microdose de cogumelos Psicodelix

Twenty percent better with 20 micrograms? A qualitative study of self-reports and discussions about psychedelic microdosing on YouTube.

Original Publication

Abstract

Bottom

Psychedelic microdosing is the practice of using small, repeated doses of psychedelic substances to facilitate a range of purported benefits. With only a few studies published so far, the subject is still under-researched and more knowledge is needed. Social media and internet discussion forums have played a vital role in the growing visibility of the microdosing phenomenon, and the present study used YouTube content to improve understanding of microdosing practice, as well as social interactions and discussions about microdosing.

Methods

Self-disclosure of microdosing in YouTube videos and subsequent comments were qualitatively analyzed using inductive thematic analysis. Several software programs were used to enable the collection and classification of relevant data.

Results

Microdosing of psychedelic substances, primarily LSD and psilocybin, has been used for therapeutic and enhancement purposes, and predominantly beneficial effects have been reported. Many different applications and results were discussed, and the therapeutic effects for depression seemed especially noteworthy. Intentional use has been recognized as an influencing factor for the progression and outcomes of microdosing. The function of social interactions was primarily to discuss viewpoints on the phenomenon of microdosing, strategies for optimal results, minimizing risks, and sharing emotional support.

Conclusions

Potentially, microdosing may provide some of the same benefits (for certain conditions) as full-dose interventions with less risk of adverse reactions related to the sometimes intense experiences of higher doses. Microdosing can also mean additional benefits, as well as risks, through repeated exposure over prolonged periods.

Bottom

Psychedelic microdosing is the practice of using small, repeated doses of psychedelic substances to facilitate a range of purported psychophysiological benefits. Mainstream media outlets have noted microdosing and described it as “the new smart drug” or “productivity hack,” improving the performance and creativity of professionals in Silicon Valley [for example, [1, 2 , 3 , 4 ] ] . The origins of psychedelic microdosing are often attributed to James Fadiman and his 2011 book “ "The psychedelic explorer's guide ". Dr. Fadiman, in turn, attributes his interest in microdosing to information he received about the personal practice of Dr. Albert Hoffman, the inventor of LSD, who supposedly used small doses of LSD for contemplative walks in nature [5]. ] .

The profound, therapeutic, and sometimes spectacular effects of high or full doses of psychedelics have been extensively researched [for example, [ 6 , 7 , 8 , 9 , 10 , 11 However, the practice of using repeated minimal doses of psychedelic substances is still poorly researched, with only a few studies published to date. Currently, we are aware of only one double-blind, placebo-controlled microdosing study. In this blind study, the perception of time was investigated, and it was discovered that microdoses of LSD produce temporal dilation of suprasecond intervals. However, only three doses were administered per individual [ 12 ]. Another microdosing study measured, but did not control for placebo, amounts of truffles containing psilocybin, exploring the effects of a single microdose on creativity as assessed by psychometric scales. Improvements in divergent and convergent thinking were found [ 13 ] In other microdosing studies, users provided their own substances and effects were assessed through self-reports, surveys, or psychometric scales. 14 , 15 , 16 , 17 ]. This approach offers less control; However, these studies had the advantage of exploring recurrent exposure over time (rather than single or few doses) that is generally intrinsic to the practice of psychedelic microdosing. They also analyzed more broadly multiple variables of potential microdosing effects and found improvements in mood, creativity and depression, greater open-mindedness, fewer dysfunctional attitudes, stress and distraction [14] , 15 , 16 , 17 ] .

It is also worth mentioning the research conducted during the 1940s-1970s exploring the minimum effective dose for psychedelic substances. A placebo-controlled study of low-dose LSD administration showed physiological (galvanic skin response) and psychological (alertness, sociability, and hedonic tone) effects at 7 μg of LSD [18] ] . The same study found pronounced psychological effects with 20 μg of LSD, including euphoria, hypomania, and distraction. Both the 20 μg and 7 μg doses produced changes in affect and energy levels during the experiment, and several subjects described this as a process of "rebirth" or "cleansing." On the other hand, other initial studies found no subjective effect from 30 μg of LSD [ 19 , 20 ]. A study of low-dose psilocybin found that doses of 2 mg were recognized by individuals [ 21 ], and another study demonstrated noticeable effects with doses as low as 6 μg per kilogram of body weight [ 22 ] Our awareness of the aforementioned early/older studies is credited to Torsten Passie and his recent book on microdosing [ 23 ] In this book, Dr. Passie also presents definitions of dose ranges and differentiates between microdosing and slightly higher "minidoses," proposing the latter as the likely culprit for noticeable acute effects commonly reported by microdosing proponents.

Social media and internet discussion forums have played an important role in the growing visibility of the microdosing phenomenon. 16 ] In recent years, the microdosing forum of Reddit.com the number of subscribers doubled annually [ 15 ] (currently around 55,000). Our interest in microdosing partly spurred our latest study of drug discussion forums, investigating the self-treatment of cluster headaches and migraines. 24 ]. One of the findings was how psychedelic microdosing worked as a successful self-treatment for headache disorders. In addition to relieving headaches, some microdosers mentioned other beneficial effects, such as increased optimism, creativity, and self-awareness. Our research team has published several studies based on data from online drug discussion forums. This exploration provided insights into the motivation and viewpoints of drug users, as well as the effects and risks of emerging psychoactive substances. 25 , 26 , 27 , 28 ]

Self-reporting and sharing of drug experiences in online drug forums have proven to be a convenient source of qualitative data for research, especially on new or under-researched substances and drug-related phenomena [e.g., [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]]. Obtaining data from social media is inexpensive and quick, and can provide information that is difficult to find from other sources, such as calls to poison control centers, survey data, or clinical research. However, a weakness in the results from the drug forum data may be a bias in the demographic profile towards a more experienced or specialized type of drug user than average, which possibly reduces the generalizability of the results. We wanted to further develop our method to obtain broader data, both demographically and in terms of content. Recognizing the growing variety of information about drugs, user stories, or disclosures of drug use published and discussed on YouTube.com We identified the need to develop our methodology to address this reality.

YouTube is expanding rapidly and has become the second most used website (and search engine) in the world. 32 ]. In doing so, it developed a unique role as an important repository of popular culture, as well as an extensive source of information on almost every conceivable subject. It is difficult to overstate the enormous impact that on-demand online video streaming has on the information landscape and how we consume, produce, and exchange information in today's society. Consequently, YouTube is an important arena for deepening awareness of how attitudes, culture, and knowledge about drug use are formed and mediated today. The combination of audio, video, text-based comments, metadata, and many interactive features of YouTube provides rich, multi-layered data freely available to researchers. However, this enormous amount of data also means challenges in developing methods for gathering, analyzing, and presenting the results.

With this research, we hope to add to previous microdosing studies that were based on limited demographic data. 12 , 13 , 16 or had exclusion criteria for participants with multiple diagnoses 12 ] Our approach does not exclude any type of microdosing user or encourage its use. We also added previous research on microdosing, including interactions and discussions among microdosers through the comments sections and other interactive features of the YouTube platform.

Look

The aim of the study was to improve understanding of the recent and contemporary phenomenon of psychedelic microdosing, as presented and discussed on the popular video-sharing platform. YouTube.com . This study was also conducted as a first step in developing a method for using YouTube as a data source for research in our field.

Methods

Data collection and procedure

The data for this study were obtained using specialized software and a YouTube API key. To obtain an initial dataset of relevant YouTube videos, a query search using the keyword “microdosing psychedelics” was conducted using Webometrics analyst software on September 19, 2018. The keyword was selected to be open-ended and not limited to a specific purpose or substance of microdosing. Our initial research yielded 84 videos, which were then manually selected and screened. Nine videos were removed for being irrelevant (lacking microdosing), duplicate uploads, or not being in English. The remaining 75 videos were examined in order to (1) obtain a comprehensive overview and (2) select all videos containing self-reports (first-hand accounts) of microdosing a psychedelic substance. The second stage generated 32 videos with self-reports that were included in the final dataset used for qualitative analysis. The 32 videos were downloaded along with their subsequent comment sections using the Ncapture browser add-on. In addition, the (automatically generated) transcripts for the 32 videos were obtained from the website https://www.diycaptions.com . The transcripts were then manually reviewed in conjunction with the video presentations, providing the researcher with the opportunity to gain an in-depth understanding of the material. The 32 video IDs were used as input for the YouTube software statistics to obtain data on views, ratings, and comments. Additionally, channel IDs were used as input for Webometric analysts to obtain data on subscribers and channel view counts. Finally, the comments, videos, and transcripts were imported into Nvivo11 for qualitative analysis.

Sample

The 32 videos contained self-reports from 34 individuals (24 men, 10 women). From the comments, we included testimonials and self-reports from 198 users. However, the gender could not be determined, as an anonymous pseudonym was the only information available about the commenters. The total duration of the included videos was 15 hours and 7 seconds, with an average duration of 36 minutes and 5 seconds. The video transcripts consisted of 142,769 words or 763,307 characters (including spaces). The comments consisted of 4507 entries. At the time of data collection, the total number of views for the included videos was 1,229,336 (average views 38,416.75). The total number of likes was 26,152 (average of 817.25), the total number of dislikes was 947 (average of 29.59), and the total number of raters was 27,099 (average of 846.84). The videos were submitted by 25 channels (or senders) with a total of 4,501.

Analysis

The transcripts and comments collected from the 32 videos were analyzed qualitatively using inductive thematic analysis, according to Braun and Clarke [ 33 ]. No initial hypothesis was used; The investigation was data-driven and coded in a completely inductive manner, although defined by the scope of the study. Since the videos and comments also contained irrelevant or off-topic content for this study, we included exclusively statements based on firsthand experiences with psychedelic microdosing. All statements that constitute mere secondhand information were ignored. Furthermore, discussions regarding the acquisition, cultivation, or production of substances were considered outside the scope and excluded. One challenge was deciding on inclusion when general viewpoints (rather than explicit self-reports) on microdosing were discussed. The guiding principle used was to include general reflections in the analysis only when the same individual also had direct personal experiences of the phenomenon being discussed. For example,

The coding was carried out at a semantic or explicit level within a realist epistemology; Interpretations of the latent content were reduced to a minimum. The checklist for thematic analysis provided by Braun and Clarke [ 33 ] was followed rigorously. In short, the process consisted primarily of reading and rereading the transcripts and commentaries. The next step was to encode basic and meaningful units of information called coded elements (CEs). A total of 1,723 CEs were then grouped into 231 basic categories or nodes. The categories were then reviewed and refined in a recursive process, going back and forth to the initial codes and evaluating their relationship to the entire dataset. The coding was verified and agreed upon independently by both authors. Next, the level of abstraction was raised, where all nodes/categories were grouped into eight overarching themes. The themes were then reviewed for consistency and finally named.

Results

The analysis revealed eight themes that illustrate the content of the self-reports and interactions of microdosing users in relation to (1) reasons, expectations and context of microdosing ; (2) enhanced states and heightened senses ; (3) insights and transformation ; (4) enhanced skills and optimal performance ; (5) Relief and cure for health problems. ; (6) unwanted side effects and lack of results ; (7) Microdosing approaches, strategies and dosage ; and (8) General viewpoints on microdosing. The topics are presented below along with illustrative quotes. Since it is not correct to label the individuals (unknowingly) who provide the self-reports for this study as “respondents” or “participants,” we will, for ease of reading, refer to them throughout as “microdosers” or “users.”

Reasons, expectations, and context of microdosing

The explicit reasons for microdosing were a form of self-treatment (e.g., disorders), self-optimization (e.g., increasing “normal” function), or a mixture of both. A small sample also mentioned exploratory motives.

Microdosing has been (in part) discussed as one of several modalities in a personal endeavor to seek health, incorporating diet, exercise, meditation, or other techniques for health, wellness, and personal development. A “holistic” approach to health has often been championed, and in this context, microdosing has been seen as a catalyst for improving overall guidance and outcomes of health efforts or self-optimization. "I was already doing things to become less anxious and depressed and to have more confidence." Things like yoga, meditation, proper nutrition, exercise, and personal development. But once I added mushrooms, it was like, "I'm on steroids." Specific trends or lifestyle orientations (e.g., biohacking, personalized medicine, and transhumanism) have also been mentioned in association with interest in microdosing.

Improvement incentives involved both physical and mental aspects and were sought by users with normal functioning, as well as in the context of limiting neuropsychiatric conditions. Those suffering from various illnesses sometimes viewed microdosing as a last resort for self-treatment when healthcare, prescribed treatments, or other methods were deemed insufficient. "I became increasingly depressed, none of the medications were working, and eventually, I became suicidal, and that's when I thought I had nothing to lose, it was better to try something crazy."

Not uncommonly, microdosers were motivated by previous experiences with high doses of psychedelics and expressed a broad interest in psychedelics. Other users had no prior experience with psychedelics or interest in psychoactive drugs and sought microdosing only as an effort to treat their conditions. "I really don't like getting high."

It was sometimes said that interest in microdosing was influenced by user stories and information from YouTube or other social media. The impact of the YouTube platform and how engagement with the microdosing trend is advancing were also demonstrated by the comments and interactions with content viewers (commenters). Both criticism and gratitude for the videos, content creators, and the views and information they provided were present in all the data. “Love your vids!” It's great to know that other people are on the same journey.” The comments section is frequently used to clarify information discussed in the videos and to ask for advice on specific health issues or recommendations for additional information resources. Great video and interview! When you quote the weight of a serving of mushrooms, are you quoting the dry weight as in powder form?

enhanced states and heightened senses

It has been said that microdosing provides a subtle but significant change in psychophysiological states, effectively serving as an all-purpose or non-specific amplifier. These (acute) effects appeared to be the basis or prerequisite for the psychological advances and improved functioning described in the following three themes. Thus, themes 3, 4, and 5 should be read as a progression or continuum stemming from the most immediate change in the states defined in this theme. However, some overlap and arbitrary division between these four themes will inevitably occur. Furthermore, the outlined progression may not, in reality, appear or manifest itself linearly on all occasions.

Most notably, the heightened states attributed to microdosing revolved around alterations in time perception and an increased (broader) sense of "presentness in the now." Because they are more present in the moment, microdosing users have reported experiencing less mental chatter and more focus, uninterrupted engagement (flow), and perceptual clarity. “I was able to simply “be” instead of constantly evaluating/analyzing/talking to myself about how things are, and that’s a feeling that has been elusive in my normal state.” The increased sense of presence and perceptual clarity signifies a qualitative improvement in the experience of the present moment, both in the form of greater visual acuity, increased awareness of sound, touch and smell, but also in the affective quality of the subjective experience. The feeling of enhanced psychophysiological functioning has been compared to "the expensive, high-quality fuel that high-performance cars need to run optimally." Not uncommonly, users noticed several enhancement effects happening simultaneously. "Visual acuity goes beyond stopping." Even with hearing and physical performance. "Leave everyone else in the dust!" Direct enhancement effects were also observed for mood, energy levels, and "drive." "I felt it as a bubbling sensation of energy, this little feeling of brightness." The effects on emotional states were further exemplified by a reduction in stress, sadness, anger, and other unwanted feelings. Furthermore, greater patience, more openness, and a sense of firmness and gratitude were mentioned as beneficial improvements in emotional states. Other psycho-spiritual changes are outlined in the following section.

Insights and transformation

An increased process of self-reflection has often been seen as central to the practice of microdosing. Microdosers provided extensive descriptions of thoughtful insights and psycho-spiritual shifts, reportedly allowing for improvements in personal orientation, priorities, and habits. Firstly, the insights discussed and the changes in propensity seemed to stem from a greater awareness and subsequent desire to live "authentically" and with more connection to nature and care for one's own needs and those of others. “Yes, microdosing can improve performance, but it also increases the chances of you doing the kind of work that can not only be a deeper alignment with yourself, but also work that will be beneficial to other people besides yourself.” A stronger sense of an authentic self and a clearer understanding of personal truths or core beliefs. They were frequently mentioned as a result of microdosing insights. "They were able to show me who I am."

A key component of the transformational processes was how latent emotional content could be evoked through microdosing, providing an opportunity to recognize and process persistent traumas or integrate a psychological "shadow" at more conscious levels of the psyche. "Microdosing revealed parts of my personality, of my nature, that I wasn't proud of and that weren't easy to face." Users of microdoses reported improved knowledge of a wide range of psychological, psychosocial, and lifestyle factors, indicating a greater capacity for emotional regulation and awareness of the impact of personal actions. Improvements in self-confidence and self-acceptance, and a subsequent decrease in social distress, allowed for a greater sense of empathy and deeper connections in personal relationships. Also,

Microdosing has also been discussed as a means of integrating previous insights and realizations gained through the use of high doses of psychedelics or other peak spiritual experiences. For these users, the practice of microdosing was seen as a way to amalgamate a spiritual experience or practice (e.g., meditation) with the "waking state" and circumstances of everyday life. It has been argued that Western society today does not present a "purer way of being," and the microdosers discussed findings on the negative impact of living in a "disconnected culture and society." "This world is infested with junk food, pornography, materialism, jealousy, and all those things." I think mushrooms connect us to a much simpler, ancient way of seeing the world. "A feeling of 'reconnection with nature' was reportedly a major and common transformative influence of microdosing." On the same note, it was described how the desire for unhealthy habits decreased significantly while motivation for more exercise, healthier eating, and less habitual use of social media was introduced. In addition, users reported less procrastination and a spontaneous urge to clean the house, tidy drawers, pay bills, or tackle other postponed or neglected tasks.

Enhanced skills and optimal performance.

As a result of the changes described earlier in psychophysiological states and, to some extent, also the insights and transformations described in the previous topic, microdosers reported a range of enhanced abilities or improved performance. Most commonly, the topics discussed included greater access to creativity and improved productivity, including convergent and divergent thinking. It was said that creative blocks or writer's block were overcome by increasing "ready-to-use thinking" and increasing enjoyment of the work. "Because you're having an abundance of creative thoughts, it allows you to take a fresh look at any work you're doing and makes things more exciting." Improved productivity and effectiveness were reported in tasks such as software development, music composition, business management, and academic work. and other cognitively intensive tasks and problem-solving. "I solve Rubik's Cubes, and when I did it with LSD, I was able to find much more efficient and faster solutions for certain cases."

The athletic performance and exercise benefits of microdosing have been exemplified by practitioners of many different sports and activities, including ice hockey, basketball, freestyle climbing, MMA, and long-distance trail running. Increased energy, focus, coordination, prediction, and overall motivation were typical benefits attributed to the use of microdosing in sports and physical exercise. "I used to play every hockey game in 10th grade on LSD, and it really heightened my senses and instincts."

A greater sense of presence, extroversion, assertiveness, or persuasiveness in social situations supposedly improved the ability to influence others and generate new relationships or work-related opportunities. "Sales meetings and marketing outreach have been easier for me than before." When I tracked the performance metrics, I saw that I performed about 20% better than without microdosing.” Enhanced leadership skills, along with greater adaptability and sensitivity to the needs and social feedback of colleagues, were other benefits mentioned regarding microdosing in a professional setting.

Relief and cure for health problems.

Various disorders or pathological functioning, often resistant to previous attempts at cure, have been supposedly relieved or alleviated by microdosing. Most commonly, depression, including long-standing major depression and other difficult-to-treat cases, has been completely cured or significantly alleviated. Microdrinking LSD was the best thing that ever happened to me. "Dealing with severe depression for 35 years... now it's over!" A decrease in anxiety was also reported (however, these results seemed more contradictory, see topic six). Several microdosers have stated how depression and anxiety were eliminated, and examples of releasing catastrophic thought patterns have been presented. Freedom from dysfunctional beliefs and improved perception of illness have been attributed to microdosing by people suffering from various psychological problems. Individuals with PTSD and bipolar disorder reported significant improvements. "I am bipolar and have used antidepressants my entire life." The only remedy that works for me is psilocybin mushrooms. I microdose and grow my own now. I've never felt better.

Drug dependence (alcohol, narcotics, prescription medications, and nicotine) has been repeatedly considered to be effectively treated by a microdosing practice. "I quit smoking after 20 years." It's like reprogramming your brain.” "It also ended my alcoholism." It has also been said that microdosing helps with motivation and lifestyle changes after addiction. "When I stopped using cannabis, my mind ended up in a very dark place." It wasn't until I started microdosing psilocybin that I was able to do something positive for myself, both physically and mentally.

Users with neuropsychiatric conditions (e.g., ADHD and ASD) have noticed improvements in cognitive and social skills. "It can help people with Asperger's learn to socialize without diminishing their love of science." At least that's what LSD and DMT did for me.” Relief from problematic stuttering has also been attributed to microdosing in some cases.

Reports of what appeared to be neurological effects of microdosing were discussed in the context of paralysis and dyspraxia (a neurological motor coordination disorder). One case involving paralysis due to spinal cord injuries reported regaining control of bladder function and also described spasms and peculiar leg movements after administering microdoses of psilocybin mushrooms. "I've also regained control of my bladder and bowel movements since starting my microdosing experiment!" It's so incredible that I want to shout it from the mountaintop and tell everyone!” Symptoms of dyspraxia were successfully treated by microdosing in a case where prescribed medications were not perceived as adequate or sufficient treatment. "Even microdosing once a month tends to alleviate the symptoms of dyspraxia." The FDA is keeping me from seeking medical treatment options because they prefer to prescribe me medication for addictive anxiety instead of treating the actual diagnosis. The intense desperation described by those suffering from treatment-resistant cluster headaches, and how microdosing cured or reduced the frequency of pain episodes, were other remarkable testimonials to the health benefits experienced.

Undesirable side effects and lack of results.

Microdosing caused some adverse effects and discomfort, but no serious events or harm were reported. Furthermore, mixed results or a lack of the desired effects were observed. More commonly, it appeared that a preferred "functional" microdose was not always established, and several examples of inadvertent overdosing were reported. In some cases, microdosers found themselves visibly affected while attending a work environment. However, this was usually discussed in a lighthearted manner as a comical or strange occurrence, rather than a significant adverse event.

As mentioned in a previous topic, the effects on anxiety have sometimes been complex or contradictory, and some users have experienced increased anxiety, or occasionally even panic attacks, discouraging its use. However, increased anxiety has also been interpreted as a function of a therapeutic or cathartic process, where increased awareness initially intensified anxiety and triggered negative emotions, as well as providing more insights and possibilities for working through personal issues. "You feel a higher degree of connection with yourself, to the point that if you have anxious thoughts or if there is something you are worrying about, it is possible that this worry will be intensified."

The feeling of being physically uncomfortable or overly aware of bodily sensations sometimes discouraged further use. Gastrointestinal discomfort and cramps, as well as increased body temperature, were other undesirable side effects reported sporadically. Furthermore, feelings of restlessness and "nervousness," compared to the potentially unpleasant effects of caffeine, were mentioned and considered to have a negative impact on the ability to concentrate. "Microdosing only made me hyperactive." This put me in a 'do' mental state instead of 'relaxing', but at the same time, I become sloppy. Great if I only need to get up to clean the house, but maybe not for solving complex problems or doing detailed work. The super-stimulant effects were more strongly associated with LSD than with other substances. Due to its long-lasting effects, LSD was sometimes said to cause insomnia. Increased impulsivity appeared to be another related effect that could mean undesirable outcomes. Excessive impulsivity was only mentioned in the context of long-term microdosing practice over many months.

The pro-social and productivity-enhancing effects reported by microdosers were negated by a smaller sample that experienced the opposite effects, with increased introversion and decreased practical or problem-solving skills. It was speculated that the incorrect (too high) dosage was to blame for these results. Decreased performance in specific cognitive domains while experiencing improvements in others—for example, less mechanical intelligence but improvements in social skills—was also mentioned.

Microdosing approaches, strategies, and dosage

Both the videos and the comments were used to advance and exchange information about practical procedures, mental preparations, or other strategies to achieve the best results. The predominant topics included dosage and administration, substance effect profiles, and precautions to minimize the risks or undesirable effects of microdosing.

The overall goal of a preferred dose appeared to be subtle but noticeable (acute) effects, but not to impair or interfere with daily activities. A typical approach was to start with approximately 1/10 of a “full” or “recreational” dose every four days for a few weeks and then have a reset period before starting a new dosing period (i.e., the “Fadiman protocol” based on Fadiman’s recommendations). 17 ]). It was also common for microdosers to establish (and recommend that others discover) a dose and dosing interval according to personal needs and preferences. But not daily. Only when I feel I need a boost. There have been many examples of users who found the typical microdose (1/10) too palpable or, in other cases, totally ineffective and adjusted their dose accordingly. "I am very sensitive to psilocybin; it's difficult for me to microdose accurately." The relationship between dosage and experiences of increased anxiety was discussed, and a strategy where dosage was gradually increased to avoid triggering anxiety was suggested. "Microdosing causes me extreme anxiety, unless I do a 'loading phase' where I increase my tolerance a little and then return to a regular microdose."

A small sample discussing entirely sub-perceptual doses for certain circumstances was also present. Typically, this approach combined a microdose of psilocybin with other non-psychoactive medicinal mushrooms and supplements for purported epigenetic neurogenesis benefits, as suggested by mycologist Paul Stamets.

The substances discussed were the classic serotonergic psychedelics, primarily LSD and psilocybin. However, analogues of both substances, such as 1P-LSD and 4-ACO-DMT, were also common. Occasional mentions of other substances such as N , N DMT, ibogaine, mescaline, 2-CB, cannabis, and 5-MeO-DALT also occurred. The effect profiles of the most common substances, for example LSD and psilocybin, not only overlap but also differ in several important ways. In addition to being longer-lasting and having more energetic effects, LSD was said to be more inclined to benefit structured and focused cognitive work, while psilocybin was more inclined to benefit emotional awareness. Some preferred 4-ACO-DMT; claiming that it provided both the cognitive clarity of LSD and the emotional awareness and grounding of psilocybin.

To promote safety and avoid harm, it was recommended to first test a given substance and dosage at home on a non-working day. Other practical and preventative recommendations included testing substances with a reagent “test kit” for the intended purpose, using a sensitive balance for accurate dosages, employing volumetric dosing (LSD), or grinding mushrooms into powder before weighing the material for greater predictability. It was also recommended to take breaks from microdosing to restart and avoid the buildup of tolerance, and to refrain from making impulsive important life decisions while under the influence.

A prevailing sentiment regarding preparation and mindset was that intentions are a vital component for the effectiveness and potential benefits of microdosing. It has typically been recommended to set clear intentions and view microdosing as a tool to facilitate the achievement of those goals. On the same note, it was also advised to let go of specific expectations and trust the process. "Have a clear and serious intention and be open to guidance and revelation." It was considered preferable to keep some form of record of the day-to-day status in order to monitor and recognize gradual changes over time. Microdosers geared towards performance and athletics sometimes also utilize various self-tracking techniques, through biometrics or other objective measures, to assess performance and avoid biases or errors in judging the effects of microdosing.

General viewpoints on microdosing

This topic summarizes the general viewpoints on microdosing discussed by users; What microdosing is, why and how it works, and how it compares to other methods or medications were predominantly deliberate topics. Discussions about the supposed mechanisms of action generally included biochemical and psycho-spiritual explanations. Scientific concepts such as neurogenesis and neuroplasticity have been attributed to feelings of increased adaptability and benefits in cognitive functioning. Improved mood, confidence, and posture were attributed to increased serotonin activity. The microdosers described how these supposed biological changes, guided by their intentions and efforts, allowed for a kind of "reprogramming of the mind-body interface." Also, More esoteric or mystical concepts, such as the presence of an intrinsic "intelligence" or "mushroom spirit" and certain "homing" properties, where mushrooms somehow impact a user's most pressing specific problems, were sometimes speculated upon. Some have conceptualized the benefits of microdosing as a form of "spiritual healing," while others have viewed it as a "psychotherapeutic tool."

A key perspective was that psychedelics differ fundamentally from established or prescribed psychiatric treatment in that they do not mask problems or facilitate passive coping, but instead can help the user recognize the root of their problems and work through them. “Instead of mitigating our emotional response to past trauma, the trauma begins to resurface, and we have to look at it and integrate it in a way that helps us become a healthier self.” The effect profile of microdosing was similarly compared to, and sometimes favored in relation to, prescribed stimulants (ADHD medications), as well as off-label stimulants used for exercise purposes. "Adderall has this feeling of forcing you to concentrate, whereas with LSD, it's more like you want to." "Microdosing was also sometimes preferred over high doses of psychedelic substances because it was a less intense and laborious process, yet still achievable through more gradual changes over time." "This gives the mushroom time to work its way into your system." I think that with anything you take more consistently, but in moderation, you give it time to work more deeply in your body.

The microdosing provided was used intentionally and in a structured manner; It was generally understood to be a relatively safe and accessible intervention, with low potential for abuse and few serious side effects. . Many users have found microdosing immensely beneficial, and several testimonials have been presented about how microdosing "saved my life" and kept me from committing suicide. Others concluded that microdosing offered certain benefits, but exercise, meditation, and other lifestyle factors were generally more critical. One of the most significant negative points discussed was the illegal status of most of the substances used, and access to microdosing prescriptions was seen as far preferable to the current situation. Some users expressed embarrassment and stigma about participating in illegal methods.

Discussion

This study provides a systematic qualitative analysis of psychedelic microdosing in a natural environment, as discussed and characterized online through... YouTube.com platform. The videos containing self-reports were often longer, unformatted discussions or video blogs by a single person and, along with the subsequent comments section, provided deep and rich qualitative data on the motivations, expectations, effects, perceived mechanisms of action, and outcomes experienced by microdosers. Furthermore, the results offer some insights into how microdosing is conducted, contextualized, and communicated among users. The reasons for microdosing, the reported effects, and the context were partially aligned with the trending (media) narrative of microdosing as a “productivity hack” or performance enhancer, but the reports from the present study were more inclined toward various forms of therapy and self-reflection (spiritual) uses. Not infrequently, there was also an overlap between self-treatment and self-optimization incentives. and many users valued various aspects of microdosing. A small subset of users mentioned exploratory motives (curiosity), but although the effects of microdosing were sometimes considered pleasant, it was not discussed as a recreational activity.

Typically, microdosing was performed in a cyclical and semi-structured regimen with the intention of personal improvement, transformation, or health. LSD and psilocybin were the most common substances, but other newer psychedelics were also used according to preference and availability. Primarily, positive or beneficial effects were reported, with fewer side effects, mostly minor. However, some users mentioned the lack of desired effects, or even the opposite, such as reduced performance for specific tasks. Possible long-term risks were considered in some videos, but no self-reported harm from long-term use was presented.

The therapeutic effects on depression appeared especially remarkable, and the reports were unanimously positive, but other mental health-related problems, such as trauma, addiction, bipolar disorder, and anxiety, were also improved or completely resolved through microdosing. Interestingly, reports involving anxiety were more disparate than for all other indications, with users also experiencing increased anxiety and negative emotions. In the microdosing study by Polito and Stevenson [ 14 A similar undesirable effect of increased neuroticism was identified. One explanation could be the anti-amnesic or revelatory properties of psychedelic substances [ 34 ] are hypothetically also present in low doses. Increased awareness of the problematic aspects of personal or other circumstances can understandably lead to heightened anxiety.

The purported beneficial effects of microdosing may seem unrealistically broad. On the other hand, evidence from full-dose psychedelic research shows a comparable range of beneficial outcomes. For example, research has provided evidence of the effectiveness of psychedelic substances in treating addiction, depression, and PTSD [for example, [ 6 , 35 , 36 ]]. Furthermore, our findings parallel positive psychology research on full-dose psychedelic use, where acute and lasting effects on mood, well-being, pro-social behaviors, cognitive flexibility, creativity, value alignment, connection with nature, personality factor openness, and mindfulness-related capabilities have been shown. 37 ]

Most of our findings regarding motivations and applications for microdosing have been addressed by at least one previous study, but, to our knowledge, some approaches and results have not been discussed before. One of them was the integration and incorporation of insights from spiritual practices (meditation), high-dose psychedelic experiences, or other peak experiences into the "normal state" of everyday life. Interactions with the everyday environment in an "enhanced state" have been claimed to facilitate the implementation of new and preferable ways of being, otherwise compartmentalized or accessible only in significantly altered states. Furthermore, a smaller sample reported improvements for dyspraxia and paralysis (from spinal cord injuries) not previously discussed in any microdosing study.

Other notable uses for microdosing have been self-treatment for neuropsychiatric conditions, cluster headaches, and as a substitute for prescribed medications. Individuals diagnosed with ADHD or ASD have reported beneficial effects from microdosing and have sometimes substituted Ritalin or Adderall with a low-dose psychedelic substance. Interestingly, the manufacturer of LSD, Dr. Albert Hoffman, proposed small doses of LSD as a suitable alternative to Ritalin with a preferable effect profile. 17 ] Microdosing has also reportedly worked as a substitute for other prescription medications seen as having inferior effect profiles (e.g., SSRIs). Previous studies have indicated successful self-treatment of headaches with psychedelics and microdosing. 24 , 38 , 39 ], and also, in the present study, microdosing was claimed as an effective strategy to decrease the intensity and frequency of cluster headaches.

The method and dataset (self-reports) used for this study can only provide rough estimates of the dosages used. Furthermore, we found that the commonly suggested starting point of 1/10 of a "recreational" or "full" dose was often considered too much for daily activities or completely ineffective, indicating high variability in sensitivity among users or in the potency and quantity of the material ingested. Furthermore, it appears both from the reports of this study, along with initial clinical data on low-dose LSD responses [ 18 The "window" between imperceptible effects and where the effects begin to adversely interfere with cognitive functioning and regular daily activities is likely to be very limited.

However, based on the qualitative insights from the present study, we suggest that the definitions of microdosing linked to fixed dose ranges [ 23 These factors may be redundant or, at least, vary too individually to be particularly useful for understanding the actual practice of microdosing or the phenomenon as it occurs, which seems more a matter of how the psychedelic substance is used. Here, the definition of microdosing is clearer; In practice, we have identified that microdosing generally means recurring, but spaced-out, doses of a psychedelic substance, small enough not to impede normal daily activities, but large enough to provide subtle, perceptible acute effects. Furthermore, reports revealed that microdosing rarely occurred without explicit and direct (usually intimate) intentions of use, and this was commonly seen as the key to all the potential and transformative processes attributed to microdosing. "On its own, it won't necessarily 'help' you, beyond a change in mood." If you microdose and sit around playing video games, it won't change your life. If you do this and focus on shifting to a new reality,

Microdosing has often been incorporated alongside other modalities or lifestyle factors for health or well-being and has been said to better support and align the direction of these efforts. Although microdosing was sometimes strongly advocated, it was not typically discussed as an effortless panacea, but rather as allowing the user to "get the ball rolling" and facilitate the process of implementing necessary changes, while also making the appropriate changes more apparent.

Facilitating self-reflection and personal insights appears to be equally valued by healthy individuals and those struggling with mental health issues. However, the taxonomy of "healthy individuals" has been challenged by the idea that most individuals carry some degree of trauma and fear that affects function and quality of life, and microdosing facilitates awareness and transcendence of these traumatic "impressions." Similar observations regarding the overlap or lack of clear distinction between therapy and enhancement use, and a questioning of the concept of “healthy” as applied to undiagnosed individuals, were also interestingly noted by respondents in Johnstad’s study [16]. ] .

The sample appeared to be relatively diverse (prior knowledge, experience with drugs, age, sex, motives), but one similarity was the willingness to take responsibility for their health and personal development, whether from a general lifestyle perspective or out of sheer desperation at not finding sufficient prescription medications, treatments, and healthcare available. The social evolution in which people increasingly turn to health information and support groups on the Internet, and a decline in the cultural authority of medical experts, are observed and addressed in studies from various academic disciplines [e.g., [40, 41, 42] ] ] our discussion on drug studies [ 24 ] and previous microdosing studies [ 16 ]. Furthermore, dissatisfaction with conventional therapies and adverse effects may encourage the use of complementary and alternative medicine (CAM). 43 ] The use of CAM has seen an increase in recent decades in the US and Europe. 43 , 44 ] At least in part, the shift in behavior toward health information seeking, CAM use, and Internet support groups (ISG) may help contextualize the growing phenomenon of microdosing.

Our review of the comments following the videos revealed several aspects of peer-to-peer support and how the collaborative creation and exchange of information on microdosing is advanced. Conversations among users (and those interested in microdosing) covered practical information about dosage, substances, safety precautions, mental preparations, and strategies for optimal results. Another function of the interactions was to comment on or correct various factual statements in the videos and to ask for clarifications and additional information, as well as to share social support and feedback. Enthusiastic claims of the benefits of microdosing prevailed, but overall, the discussions were reasonably nuanced, aware of the risks, and generally seemed to stem from an intention of personal and mutual improvement.

Our findings were, in general, consistent with previous microdosing studies [ 13 , 14 , 15 , 16 , 17 However, at present, there is no way to distinguish the reported results from placebo or how expectations or other lifestyle factors and interventions influence the results. In our opinion, expectations are likely to impact both negative and positive outcomes. However, considering that psychedelic substances appear to be physiologically active in microdosing ranges [ 18 ], and the various known mechanisms of action from psychedelic neuroscience [ 37 ], the overall credibility of the reported results does not seem improbable in principle. Potentially, microdosing could provide some of the same benefits (for certain conditions) as full-dose interventions with less risk of adverse reactions related to the sometimes intense experiences of higher doses. Microdosing can also mean additional benefits, as well as risks, through repeated exposure over prolonged periods. Furthermore, considering how use typically occurs in an "everyday context" while interacting with familiar work-related tasks and personal relationships, new applications and benefits not attainable through occasional and drastically altered states of full doses are plausible.

Limitations, strengths, and future research.

This study used a novel and innovative methodology to obtain and process YouTube search data, and therefore we took extra care to describe the approach in full detail. Naturally, there is room for improvement or modification, and to fully understand the potential usefulness of the method, it should be evaluated more thoroughly and applied to additional research projects. So far, the approach appears to be effective and shows potential to be useful in future research. One challenge of the method is the large amount of data a topic can generate and how to classify, discern, and present relevant information in a consistent manner.

We believe that one of the main strengths of the study is its broad and truly inductive approach and the absence of preconceived research questions or other researcher constructs. One apparent limitation of this study is the difficulty in controlling the conditions surrounding drug use (e.g., dosage, type of substance, combinations with other drugs or medications). Self-selected and non-randomized sampling can contribute to bias, and the accuracy of the reports cannot be guaranteed. The reported therapeutic results may be questioned as selective reporting or incorrect recall. However, if inconsistent reporting was the reason for the robust results in depression, we suggest that the same would be true for anxiety, where treatment outcomes have been highly contradictory.

We also recognize that it is unlikely that a generalizable sample would post self-disclosure videos of illegal drug use on YouTube. However, a predominant portion of the self-reports used for the present study was derived from the comment sections, where users can be completely anonymous and are unlikely to be censored or reprimanded for such disclosure. Furthermore, considering the general nature of YouTube use and the videos being posted in eight separate YouTube categories, by 25 channels, with a total of 4.5 million subscribers, we suggest that the present sample consists of a less “specialized” demographic group than in any available drug discussion forum.

For future clinical research, we suggest incorporating the variable of personal intentions. If microdosing is primarily used as a tool to achieve personal goals, this variable should be carefully considered. The narrow and individually variable dose window of a psychedelic microdose observed in the present study is also essential to take into consideration. Ignoring these factors risks producing distorted results, where potentially essential outcomes, otherwise present in a context where the microdoser adjusts the dose and frequency according to personal preference and situation, may be overlooked.

Conclusions

Microdosing with various psychedelic substances, primarily LSD and psilocybin, has been used for therapeutic and enhancement purposes, and mostly beneficial effects have been reported. The therapeutic effects for depression seemed particularly noteworthy. Many different applications and outcomes were discussed, and the function of the interactions was primarily to exchange viewpoints on the phenomenon of microdosing, develop strategies for optimal results, minimize risks, and share social support. The therapeutic results appeared to be supported by microdosing in a self-reinforcing process: (1) motivation to deal with problems was raised by immediate increases in mood, energy, presence and attention; (2) awareness of problems and solutions was increased by access to new perspectives, a sense of reconnection with an authentic self and core beliefs; and (3) the change in habits and mindset was facilitated by a greater affinity for healthy lifestyle factors and a greater sense of adaptability. The intended use was recognized as an important factor in the microdosing results. The current trend of microdosing and its purported health benefits are highly interesting, but questions about long-term risks remain unanswered, and the potential benefits require further evidence.

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